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?1A). The larger Ca2+ accessibility is important for that activation with the NF-��B along with NFAT transcription aspects, both essential for the transcription of countless cytokine family genes, which includes IL-6, TNF-��, as well as IL-13 [9]. Just like IP3, DAG can be required for typical mast cell responses. Both phospholipase D1/2 (PLD1/2) as well as DAG kinase �� (DGK��) perform a crucial


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